The Role of Exosomal Long Non-Coding RNAs in Tumors and Tumour Metabolism

Yaomin Luo; Yanhong Liu; Zhen Jiang

doi:doi:10.11648/j.ajbls.20241203.13

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The Role of Exosomal Long Non-Coding RNAs in Tumors and Tumour Metabolism

Yaomin Luo

, Yanhong Liu

, Zhen Jiang^*

Published in American Journal of Biomedical and Life Sciences (Volume 12, Issue 3)

Received: 10 July 2024 Accepted: 12 August 2024 Published: 27 August 2024

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Abstract

Long non-coding RNAs (lncRNAs) are RNAs that do not have protein-coding functions and are involved in a wide range of important regulatory processes through four modes of (1) signaling (2) guidance (3) structural backbone (4) decoying, which regulate gene expression at epigenetic, transcriptional and post-transcriptional levels. Exosomes are extracellular vesicles released by various cells, whose contents are protected from degradation and stabilized in the extracellular environment due to their lipid bilayer membrane structure, and which are thought to play an important role in many diseases, including tumors. The exosomes secreted by tumor cells and stromal cells contain proteins, nucleic acids, lipids, cytokines, transcription factors and other biologically active substances. With the help of exosomes, they are stably transported between cells and mediate the exchange of substances and information between cells in order to achieve intercellular communication, thus affecting the biological activities of target cells. Among them, lncRNAs are selectively sorted into exosomes, which can regulate tumor metabolism as well as tumor progression through exosomes in various ways. In this paper, the role of exosomal lncRNAs in the tumor microenvironment and tumor metabolism is reviewed, with a view to providing markers, targets and directions for clinical diagnosis, tumor therapy and tumor-related research.

Published in	American Journal of Biomedical and Life Sciences (Volume 12, Issue 3)
DOI	10.11648/j.ajbls.20241203.13
Page(s)	49-56
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Exosomes, Long Non-Coding RNA, Tumor Microenvironment, Tumor Metabolism

References

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Cite This Article

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APA Style

Luo, Y., Liu, Y., Jiang, Z. (2024). The Role of Exosomal Long Non-Coding RNAs in Tumors and Tumour Metabolism. American Journal of Biomedical and Life Sciences, 12(3), 49-56. https://doi.org/10.11648/j.ajbls.20241203.13

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ACS Style

Luo, Y.; Liu, Y.; Jiang, Z. The Role of Exosomal Long Non-Coding RNAs in Tumors and Tumour Metabolism. Am. J. Biomed. Life Sci. 2024, 12(3), 49-56. doi: 10.11648/j.ajbls.20241203.13

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AMA Style

Luo Y, Liu Y, Jiang Z. The Role of Exosomal Long Non-Coding RNAs in Tumors and Tumour Metabolism. Am J Biomed Life Sci. 2024;12(3):49-56. doi: 10.11648/j.ajbls.20241203.13

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@article{10.11648/j.ajbls.20241203.13,
  author = {Yaomin Luo and Yanhong Liu and Zhen Jiang},
  title = {The Role of Exosomal Long Non-Coding RNAs in Tumors and Tumour Metabolism
},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {12},
  number = {3},
  pages = {49-56},
  doi = {10.11648/j.ajbls.20241203.13},
  url = {https://doi.org/10.11648/j.ajbls.20241203.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20241203.13},
  abstract = {Long non-coding RNAs (lncRNAs) are RNAs that do not have protein-coding functions and are involved in a wide range of important regulatory processes through four modes of (1) signaling (2) guidance (3) structural backbone (4) decoying, which regulate gene expression at epigenetic, transcriptional and post-transcriptional levels. Exosomes are extracellular vesicles released by various cells, whose contents are protected from degradation and stabilized in the extracellular environment due to their lipid bilayer membrane structure, and which are thought to play an important role in many diseases, including tumors. The exosomes secreted by tumor cells and stromal cells contain proteins, nucleic acids, lipids, cytokines, transcription factors and other biologically active substances. With the help of exosomes, they are stably transported between cells and mediate the exchange of substances and information between cells in order to achieve intercellular communication, thus affecting the biological activities of target cells. Among them, lncRNAs are selectively sorted into exosomes, which can regulate tumor metabolism as well as tumor progression through exosomes in various ways. In this paper, the role of exosomal lncRNAs in the tumor microenvironment and tumor metabolism is reviewed, with a view to providing markers, targets and directions for clinical diagnosis, tumor therapy and tumor-related research.
},
 year = {2024}
}

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TY  - JOUR
T1  - The Role of Exosomal Long Non-Coding RNAs in Tumors and Tumour Metabolism

AU  - Yaomin Luo
AU  - Yanhong Liu
AU  - Zhen Jiang
Y1  - 2024/08/27
PY  - 2024
N1  - https://doi.org/10.11648/j.ajbls.20241203.13
DO  - 10.11648/j.ajbls.20241203.13
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 49
EP  - 56
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20241203.13
AB  - Long non-coding RNAs (lncRNAs) are RNAs that do not have protein-coding functions and are involved in a wide range of important regulatory processes through four modes of (1) signaling (2) guidance (3) structural backbone (4) decoying, which regulate gene expression at epigenetic, transcriptional and post-transcriptional levels. Exosomes are extracellular vesicles released by various cells, whose contents are protected from degradation and stabilized in the extracellular environment due to their lipid bilayer membrane structure, and which are thought to play an important role in many diseases, including tumors. The exosomes secreted by tumor cells and stromal cells contain proteins, nucleic acids, lipids, cytokines, transcription factors and other biologically active substances. With the help of exosomes, they are stably transported between cells and mediate the exchange of substances and information between cells in order to achieve intercellular communication, thus affecting the biological activities of target cells. Among them, lncRNAs are selectively sorted into exosomes, which can regulate tumor metabolism as well as tumor progression through exosomes in various ways. In this paper, the role of exosomal lncRNAs in the tumor microenvironment and tumor metabolism is reviewed, with a view to providing markers, targets and directions for clinical diagnosis, tumor therapy and tumor-related research.

VL  - 12
IS  - 3
ER  -

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Author Information

Yaomin Luo

Department of Rehabilitation Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, China

Contact Email

http://orcid.org/0000-0001-9569-6810
Yanhong Liu

Faculty of Medicine and Health, The University of Sydney, Sydney, Australia

Contact Email

http://orcid.org/0009-0004-4373-5856
Zhen Jiang

Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Nanchong, China

Contact Email

http://orcid.org/0000-0003-3006-3056

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Plain Text BibTeX RIS

APA Style

Luo, Y., Liu, Y., Jiang, Z. (2024). The Role of Exosomal Long Non-Coding RNAs in Tumors and Tumour Metabolism. American Journal of Biomedical and Life Sciences, 12(3), 49-56. https://doi.org/10.11648/j.ajbls.20241203.13

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ACS Style

Luo, Y.; Liu, Y.; Jiang, Z. The Role of Exosomal Long Non-Coding RNAs in Tumors and Tumour Metabolism. Am. J. Biomed. Life Sci. 2024, 12(3), 49-56. doi: 10.11648/j.ajbls.20241203.13

Copy | Download

AMA Style

Luo Y, Liu Y, Jiang Z. The Role of Exosomal Long Non-Coding RNAs in Tumors and Tumour Metabolism. Am J Biomed Life Sci. 2024;12(3):49-56. doi: 10.11648/j.ajbls.20241203.13

Copy | Download

@article{10.11648/j.ajbls.20241203.13,
  author = {Yaomin Luo and Yanhong Liu and Zhen Jiang},
  title = {The Role of Exosomal Long Non-Coding RNAs in Tumors and Tumour Metabolism
},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {12},
  number = {3},
  pages = {49-56},
  doi = {10.11648/j.ajbls.20241203.13},
  url = {https://doi.org/10.11648/j.ajbls.20241203.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20241203.13},
  abstract = {Long non-coding RNAs (lncRNAs) are RNAs that do not have protein-coding functions and are involved in a wide range of important regulatory processes through four modes of (1) signaling (2) guidance (3) structural backbone (4) decoying, which regulate gene expression at epigenetic, transcriptional and post-transcriptional levels. Exosomes are extracellular vesicles released by various cells, whose contents are protected from degradation and stabilized in the extracellular environment due to their lipid bilayer membrane structure, and which are thought to play an important role in many diseases, including tumors. The exosomes secreted by tumor cells and stromal cells contain proteins, nucleic acids, lipids, cytokines, transcription factors and other biologically active substances. With the help of exosomes, they are stably transported between cells and mediate the exchange of substances and information between cells in order to achieve intercellular communication, thus affecting the biological activities of target cells. Among them, lncRNAs are selectively sorted into exosomes, which can regulate tumor metabolism as well as tumor progression through exosomes in various ways. In this paper, the role of exosomal lncRNAs in the tumor microenvironment and tumor metabolism is reviewed, with a view to providing markers, targets and directions for clinical diagnosis, tumor therapy and tumor-related research.
},
 year = {2024}
}

Copy | Download

TY  - JOUR
T1  - The Role of Exosomal Long Non-Coding RNAs in Tumors and Tumour Metabolism

AU  - Yaomin Luo
AU  - Yanhong Liu
AU  - Zhen Jiang
Y1  - 2024/08/27
PY  - 2024
N1  - https://doi.org/10.11648/j.ajbls.20241203.13
DO  - 10.11648/j.ajbls.20241203.13
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 49
EP  - 56
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20241203.13
AB  - Long non-coding RNAs (lncRNAs) are RNAs that do not have protein-coding functions and are involved in a wide range of important regulatory processes through four modes of (1) signaling (2) guidance (3) structural backbone (4) decoying, which regulate gene expression at epigenetic, transcriptional and post-transcriptional levels. Exosomes are extracellular vesicles released by various cells, whose contents are protected from degradation and stabilized in the extracellular environment due to their lipid bilayer membrane structure, and which are thought to play an important role in many diseases, including tumors. The exosomes secreted by tumor cells and stromal cells contain proteins, nucleic acids, lipids, cytokines, transcription factors and other biologically active substances. With the help of exosomes, they are stably transported between cells and mediate the exchange of substances and information between cells in order to achieve intercellular communication, thus affecting the biological activities of target cells. Among them, lncRNAs are selectively sorted into exosomes, which can regulate tumor metabolism as well as tumor progression through exosomes in various ways. In this paper, the role of exosomal lncRNAs in the tumor microenvironment and tumor metabolism is reviewed, with a view to providing markers, targets and directions for clinical diagnosis, tumor therapy and tumor-related research.

VL  - 12
IS  - 3
ER  -

Copy | Download