Special Issue on Inflammatory Bowel Disease

Submission Deadline: May. 25, 2020

This special issue currently is open for paper submission and guest editor application.

  • Special Issue Editor
    • Nirmal Verma
      Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA
    Guest Editors play a significant role in a special issue. They maintain the quality of published research and enhance the special issue’s impact. If you would like to be a Guest Editor or recommend a colleague as a Guest Editor of this special issue, please Click here to fulfill the Guest Editor application.
    • Ravi Verma
      Pohang University of Science and Technology, Gyeongbuk, South Korea
    • Anil Verma
      Indian Council of Medical Research, New Delhi, India
    • Reena Kumari
      University of Kentucky, Kentucky, USA
    • Raju Ranjha
      National Institute of Malaria Research, Rourkela, India
    • Naresh Kumar Meena
      NIH, Bethesda, USA
    • Jaishree Paul
      Jawaharlal Nehru University, New Delhi, India
  • Introduction

    Ulcerative colitis (UC) and Crohn’s disease (CD) are chronic inflammatory disorders of the intestinal tract. They are summarized as inflammatory bowel disease (IBD). In UC, the inflammation occurs in the mucosa and mucosal ulceration can develop. UC is mainly localized in the rectum and spreads to proximal parts of the intestine to a different extent. In CD, any part of the gastrointestinal tract can be affected, however the main site of inflammation is the terminal ileum and inflammation can occur segmental and discontinuously. In contrast to UC, not only the mucosa is affected but also all layers of the intestinal wall and granuloma are formed in CD. The pathogenesis of both diseases is not yet fully elucidated. Different factors such as genetics, immune dysregulation, and the microbial flora in the intestine and barrier dysfunction of intestinal epithelial cells may lead to the pathology of IBD. The pathogenesis of IBD is poorly understood because of the variability in clinical manifestations and complexity of the mechanisms of chronic inflammation.
    There is increasing evidence that IBD tissue injury involves many cell types present in the bowel wall. The epithelial cell has been traditionally considered an important component of IBD pathogenesis, especially in UC. Due to the variability, complexity, and chronicity of gut inflammation in IBD, intestinal epithelial cells (IEC) constantly adapt to the multiple events occurring in the mucosal microenvironment, a phenomenon that has been long recognized. This adaptation might cause IEC to undergo changes in growth and differentiation, metabolism, secretary pattern, immune function, and antigen expression.
    Taking into account the practical importance of searching for new effective approaches for Inflammatory Bowel Diseases treatment and prevention, we dedicate a special issue of the journal to this problem.

    Aims and Scope:

    1. Ulcerative colitis
    2. Crohn’s disease
    3. Gut Immunology
    4. Gut genetic factors
    5. Gut Microbiota
    6. Gut micro RNA

    Relevant topics that would be considered for inclusion in this special issue include, but are not limited to:

  • Guidelines for Submission

    Manuscripts can be submitted until the expiry of the deadline. Submissions must be previously unpublished and may not be under consideration elsewhere.

    Papers should be formatted according to the guidelines for authors (see: http://www.ajbls.org/submission). By submitting your manuscripts to the special issue, you are acknowledging that you accept the rules established for publication of manuscripts, including agreement to pay the Article Processing Charges for the manuscripts. Manuscripts should be submitted electronically through the online manuscript submission system at http://www.sciencepublishinggroup.com/login. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal and will be listed together on the special issue website.

  • Published Papers

    The special issue currently is open for paper submission. Potential authors are humbly requested to submit an electronic copy of their complete manuscript by clicking here.

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