Special Issue on The Influence of Estrogen in Development and Prognosis of Cancer

Submission Deadline: Apr. 10, 2020

Please click the link to know more about Manuscript Preparation: http://www.ajbls.org/submission

This special issue currently is open for paper submission and guest editor application.

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Special Issue Flyer (PDF)
  • Lead Guest Editor
    • Jerónimo Rodríguez-Cid
      Department of Oncology, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosio Villegas”, Mexico city, Mexico
  • Guest Editor
    Guest Editors play a significant role in a special issue. They maintain the quality of published research and enhance the special issue’s impact. If you would like to be a Guest Editor or recommend a colleague as a Guest Editor of this special issue, please Click here to complete the Guest Editor application.
    • Jorge Alatorre-Alexander
      Department of Oncology, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosio Villegas”, Mexico city, Mexico
    • Vanessa García-Montes
      Department of Oncology, Hospital Español, Mexico city, Mexico
    • Hector Martinez-Said
      Department of Oncology, Instituto Nacional de Cancerología, Mexico city, Mexico
    • Carla Lopez-Espinosa
      Department of Neurobiology, Universidad Nacional Autonoma de México, Mexico city, Mexico
    • Osvaldo Hernandez-Flores
      Department of Oncology, ISSSTE Hospital Regional Bicentenario de la Independencia, Mexico city, Mexico
    • Ivan Gonzalez-Espinoza
      Department of Oncology, Hospital Angeles de Puebla, Mexico city, Mexico
  • Introduction

    Beyond the widespread physiological implications of the estrogens in human cells, there is a central role of the estrogens in the cancer pathway. In this special issue, we will review the molecular influence of the different subtypes of estrogen receptors as a promoter or as an inhibitor in the cancer pathogenesis.
    We can say that there is a relation between the estrogen levels and his exposure time with the development risk of breast and endometrium cancer, however, in different neoplasm such as ovarian cancer, works as a protector factor. Using the aforementioned as a premise, different researches have shown prognostic value in breast cancer, lung cancer, mesothelioma, among others. The heterogeneous effect of estrogens in tumoral cells could lie in the specific estrogen receptor (ER) subtype that is stimulated. Some examples of the influence of ER in cancer are: 1) The ERα and his promoting effects in breast cancer, although the role of the β subtype of this receptor still uncertain, elucidating his paper in the pathogenesis of breast cancer still remains relevant given their common prevalence in these tumor cells and some evidences that natural or synthetic ERβ-selective estrogens may lack breast cancer-promoting properties exhibited by estrogens in hormone replacement regimens and may be useful for chemoprevention of breast cancer. 2) In healthy lung tissue, ERβ is highly expressed in pneumocytes and in the bronchial epithelial cells, and is required for the maintenance of the extracellular matrix of the lung, as well as in healthy lung tissue, ER are consistently found in lung cancer tissues and cell lines, especially adenocarcinoma, and mostly in the form of the ERβ. Estrogen has been reported to adversely affect the prognosis of lung cancer patients. However, there are several studies with conflicting results about the effect of estrogen on the risk and/or survival of lung cancer. 3) Finally, our research group found recently that high and moderate expression of ERβ in advanced clinical stage malignant pleural mesothelioma was associated with a tendency of higher overall survival and better response to chemotherapy treatment resulting in longer progression-free survival. Some studies also have demonstrated that using a selective agonist of ERβ decreases the growth of malignant pleural mesothelioma cells in both in vitro and in murine models, as well as an increase in the sensitivity to the anti-tumor treatment.
    This varied interaction between different estrogen receptors and their effects on different types of cancer makes it an exciting topic that leaves a niche of knowledge to understand and redesign new therapeutic strategies against molecular mediators to assist in cancer treatment and disease management.

    Aims and Scope:

    1. Comprehend the function of estrogens in cancer
    2. Elucidate the prognosis role of the estrogen receptor subtypes in cancer
    3. Highlight some of the most important outcomes related to estrogen receptor and cancer
    4. Describe the niche of knowledge of estrogen receptor β in breast cancer
    5. Specify some of the differences between the estrogen receptor α and β in cancer
    6. Emphasize the potential role of estrogen receptor subtypes in cancer

  • Guidelines for Submission

    Manuscripts can be submitted until the expiry of the deadline. Submissions must be previously unpublished and may not be under consideration elsewhere.

    Papers should be formatted according to the guidelines for authors (see: http://www.ajbls.org/submission). By submitting your manuscripts to the special issue, you are acknowledging that you accept the rules established for publication of manuscripts, including agreement to pay the Article Processing Charges for the manuscripts. Manuscripts should be submitted electronically through the online manuscript submission system at http://www.sciencepublishinggroup.com/login. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal and will be listed together on the special issue website.

  • Published Papers

    The special issue currently is open for paper submission. Potential authors are humbly requested to submit an electronic copy of their complete manuscript by clicking here.